Nicotinamide riboside (NR) is now known to be an NAD+ precursor, involved in the biosynthetic pathways that convert B3 vitamins into NAD+. NAD+ is primarily synthesized in mammals de novo from tryptophan, through the Priess-Handler pathway from nicotinic acid (NA) or via a salvage pathway from nicotinamide (NAM).
know to help with: boosts energy, DNA repair, Improves cognitive function, Pain management, Addiction, Weight management, Boost metabolism, Decreasing inflammation, And improved cognition.
NAD+ plays a pivotal role in cellular metabolism and is a co-substrate for enzymes that play key roles in pathways that modify aging. Thus, interventions that increase NAD+ may slow aspects of the aging trajectory, and there is great interest in methods for cellular NAD+ restoration.
Moreover, NAD+ has been found to enhance mitochondrial function, the powerhouse of the cell responsible for energy production. By optimizing mitochondrial activity, NAD+ can boost metabolism and promote the conversion of stored fat into energy, further supporting weight loss goals.
Due to its potential link to anti-aging, experts suggest that NAD supplementation might reduce nerve cell inflammation, which can contribute to age-related cognitive disorders like Parkinson’s disease.
Keep in mind, though, that there’s very little evidence that these supplements are effective in humans. Do NAD+ supplements really work? It is not known. Despite some effectiveness in animal models, strong clinical trials are needed before NAD+ supplements can be recommended.
People with liver or kidney issues should avoid NAD+ supplements since these organs are key for metabolism of NAD+ supplements. Additionally, those who are pregnant or breastfeeding should consider not taking them since more research is needed to see if there are any potential harms.