NAD+,

• NAD+ (nicotinamide adenine dinucleotide) is a coenzyme that supports many of the body’s biological processes. NAD+ helps protect cells from stress, supports healthy sleep cycles, and helps repair damaged DNA Nicotinamide riboside (NR) is now known be an NAD+ precursor involved in the biosynthetic pathways that convert B3 vitamins into NAD+. NAD+ is primarily synthesized in mammals de novo from tryptophan, through the Priess-Handler pathway from nicotinic acid (NA), or via a salvage pathway from nicotinamide (NAM).

Nad+ is known to help with boosting energy, DNA repair, improving cognitive function, pain management, addiction, weight management, boosting metabolism, decreasing inflammation, and improving cognition. NAD+ plays a pivotal role in cellular metabolism and is a co-substrate for enzymes that play key in pathways that modify aging. Thus, interventions that increase NAD+ may slow aspects of the aging trajectory, and there is great interest in methods for cellular NAD+ restoration.

Moreover, NAD+ has been found to enhance function, the powerhouse of the cell responsible for energy production. By optimizing mitochondrial activity, NAD+ boost metabolism and promote the conversion of stored fat into, further supporting weight loss goals. Due to its potential link to anti-aging, experts suggest that NAD+ supplementation might reduce nerve cell inflammation, which can contribute to age-related cognitive disorders like Parkinson’s disease.

Keep in mind, though, that there is very little evidence that these supplements are effective in humans. Do NAD+ supplements really work? It is not known. Despite some effectiveness in animal models, strong clinical trials are needed before NAD+ supplements can be recommended. People with liver or kidney issues should avoid NAD+ supplements since these organs are key for the metabolism of NAD+ supplements. Additionally, those who are pregnant or breastfeeding should consider avoiding NAD+ supplements.