Semaglutide is an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management. It is a peptide similar to the hormone glucagon-like peptide-1, modified with a side chain
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Semaglutide CAS #910463-68-2
Disclosure! These peptides have not been evaluated by the FDA. These peptides are not a form of medication and are for research purposes only. Purchasing research peptides for personal use is illegal.
| Property | Value |
|---|---|
| Type | Synthetic GLP-1 receptor agonist |
| Molecular formula | C<sub>187</sub>H<sub>291</sub>N<sub>45</sub>O<sub>59</sub> |
| Molecular weight | 4113.58 g/mol |
| CAS Number | 910463-68-2 |
| PubChem CID | 56843341 |
| Structure type | Modified 31-amino acid peptide (based on native GLP-1) |
Semaglutide is a GLP-1 analogue (94% homologous to native human GLP-1) with three key modifications:
Amino acid substitution:
Ala8 → Aib (aminoisobutyric acid) → prevents degradation by DPP-4 enzyme
Fatty acid side chain:
C18 fatty diacid attached to Lys26 via a glutamic acid-based spacer
Promotes albumin binding → extends half-life to ~7 days (once-weekly dosing)
Amide modification:
The N-terminus is acetylated to increase stability
Modified at positions 8 (Aib) and 26 (Lys fatty-acylation)
Designed to mimic GLP-1 while resisting enzymatic degradation
| Property | Semaglutide |
|---|---|
| Class | GLP-1 receptor agonist |
| Origin | Modified human GLP-1 (7–37) |
| Length | 31 amino acids |
| Key Modifications | Aib substitution, fatty acid side chain |
| Half-life | ~7 days |
| Uses | Research Only |
| Weight | .0128 lbs |
|---|---|
| Dimensions | .75 × .75 × 1.5 in |
| mg | 10mg, 5mg, 2mg |
Handle only in an appropriate laboratory environment by qualified personnel using suitable PPE and institutional safety procedures. Review the SDS before handling. Biotech Labz Supply does not provide medical, veterinary, dosing, administration, or product-use advice.
